• br Disclosure br Acknowledgement br

  2024-01-27

  

  Disclosure Acknowledgement Introduction CYP17A1 is a multifunctional enzyme with both 17α-hydroxylase and 17,20-lyase activities and is essential for the biosynthesis of steroidal Obeticholic Acid in male testes and adrenal glands. The 17α-hydroxylase activity of CYP17A1 is involved in the

• br Materials and methods br

  2024-01-27

  

  Materials and methods Results To explore the potential role of autophagy in drug resistance, we firstly performed immunohistochemistry to compare the Lamivudine of p62 in paired primary, metastatic, and recurrent tumor tissues from 26 ovarian cancer patients. The expression of p62 was reveale

• br Role of autophagy in alcoholic cardiomyopathy

  2024-01-27

  

  Role of autophagy in alcoholic cardiomyopathy Concluding remarks The genetic and phenotypic heterogeneity in alcoholic cardiac injury has been recognized despite the seemingly beneficial effects of low to moderate alcohol consumption [8]. Although oxidative stress is well established in the pa

• The synthetic route for the aminobenzoxazole scaffold

  2024-01-27

  

  The synthetic route for the aminobenzoxazole scaffold with a solvent accessible moiety is described in . Nitration of methoxyphenol and subsequent hydrogenation of the resulting nitro apramycin receptor afforded compound . Aminobenzoxazole was formed by the reaction of compound with BrCN in EtOH.

• We have recently reported a regulatory effect of quercetin

  2024-01-27

  

  We have recently reported a regulatory effect of quercetin on the AChE activity in the brainstem during the demyelination and remyelination process [17]. It has also been observed that there is a protective effect on lipid peroxidation and worsening of motor functions caused by loss of myelin in the

• br Asthma The chronic airway inflammatory disease asthma

  2024-01-26

  

  Asthma The chronic airway inflammatory disease Fluconazole is associated with enhanced levels of exhaled NO generated by iNOS in the airway epithelium [12]. In asthmatic patients local and systemic changes in iNOS, peroxynitrite, arginase, ADMA and arginine levels have been observed and are asso

• In glucose stimulated pancreatic cells B Raf activity is

  2024-01-26

  

  In glucose-stimulated pancreatic β-cells, B-Raf activity is increased, while Raf-1 activity is under the detection limit (Duan and Cobb, 2010). Thus, B-Raf is the primary protein kinase involved in the rapid activation of ERK1/2 in glucose-treated pancreatic β-cells. Expression of a dominant-negativ

• br Summary br Introduction With

  2024-01-26

  

  Summary Introduction With readily synthetic methods and excellent chemical/physical characteristics, coumarins have received extensive attention and show great practical values in many fields, such as medicine discovery, dye chemistry, materials chemistry and so on [[1], [2], [3]]. Actually, o

• Cellular detoxification is an important

  2024-01-26

  

  Cellular detoxification is an important process that helps remove excess oxidants from the cellular environment through endogenous antioxidants or other molecules capable of reduction. One of the key regulators of antioxidant production is the transcription factor, nuclear factor (erythroid-derived

• Our observation that squalestatin caused

  2024-01-26

  

  Our observation that squalestatin caused only small differences in the production of Aβ40 and Aβ42 was in contrast to prior reports of the effects of other cholesterol synthesis inhibitors. This may be due to using squalestatin, a more specific cholesterol synthesis inhibitor that does not affect is

• In another study Yerra and Kumar used streptozotocin

  2024-01-26

  

  In another study, Yerra and Kumar (2016) used streptozotocin to induce diabetic neuropathy in rats. Mechanical/thermal hyperalgesia, motor/sensory nerve conduction velocities (MNCV and SNCV) and sciatic nerve blood flow (NBF) were evaluated. In vitro studies of Neuro2a (N2A) cell culture were perfor

• Circular dichroism CD provides useful information

  2024-01-26

  

  Circular dichroism (CD) provides useful information about protein structure, the extent and rate of structural changes and ligand binding. CD is a form of light Efavirenz spectroscopy that measures differences in the absorbance of right- and left-circularly polarized light (rather than the commonly

• br The lipoxygenase pathway in vascular physiology and

  2024-01-26

  

  The 12/15-lipoxygenase pathway in vascular physiology and pathology The mammalian 12- and 15-LOXs have high substrate specificity oxidizing predominantly ω−6 (arachidonic and linoleic acids) but also the ω−3 (docosahexanoic) X-Gal [86], [87], [88]. Different LOXs oxidize fatty acids both in the

• In a recent series of studies from

  2024-01-26

  

  In a recent series of studies from our laboratory, to characterize the contractile systems within the rat ML347 wall, three conditions were identified that led to detrusor activity: spontaneous micro-contractions, electrical field stimulated (EFS) contractions and muscarinic agonist induced contrac

• To understand the kinase selectivity profile of this series

  2024-01-26

  

  To understand the kinase selectivity profile of this series, Gabapentin , as a representative analog from this series, was profiled against 216 purified protein kinases representing the tyrosine and serine/threonine kinase families using an in-house Caliper EZ Reader mobility shift assay. Assays we

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