• Cx is a phosphoprotein that is predominantly phosphorylated

  2022-02-23

  

  Cx43 is a phosphoprotein that is predominantly phosphorylated in the control state. Cx43 can be phosphorylated by a number of kinases and dephosphorylated by protein phosphatases such as PP1 and PP2A [6], [10]. Posttranslational phosphorylation of Cx43 is thought to influence intercellular coupling

• br Results br Discussion In this study

  2022-02-23

  

  Results Discussion In this study, we investigated the role of galanin and GAL2 receptors on anxiety-like behaviours mediated by the dorsal hippocampus of rats. We showed that locally administered galanin (1 nmol) decreased exploration of the open arms in the EPM, suggesting an anxiogenic-like

• Psoriasis is an inflammatory skin disease characterized

  2022-02-23

  

  Psoriasis is an inflammatory skin disease characterized by epidermal hyperplasia; micro-abscesses; neo-angiogenesis; a proinflammatory cytokine environment involving alterations of IL-17A, IL-23, and TNF-α; and activation of and infiltration by macrophages, mast cells, neutrophils, CD11c+ dendritic

• Since our new compound Fex could be

  2022-02-23

  

  Since our new compound Fex-3 could be a new FXR ligand, we try to demonstrate that Fex-3 was an intestinal-restricted FXR agonist which only activated FXR in the intestine not in the liver or other organs. Initially, we investigated this in Caco-2 YM201636 australia with transwell experiments. From

• br FXR FGF in the control of BAs synthesis

  2022-02-23

  

  FXR–FGF15/19 in the control of BAs synthesis The nuclear receptor FXR is the master regulator of BAs homeostasis, modulating their synthesis, ache inhibitor and uptake [15]. FXR decreases BA de novo hepatic biosynthesis by reducing the expression of CYP7A1. At the canalicular membrane, newly-syn

• Further our data demonstrate a role for mitochondrial AIF in

  2022-02-23

  

  Further, our data demonstrate a role for mitochondrial AIF in oxidative cell death induced by RSL3. We found that AIF knockdown using siRNA completely protected the hdac inhibitors against RSL3 induced oxidative stress. Similar to other pathways of caspase-independent programmed cell death, mitocho

• In principle an ideal Fenton reaction element should have mu

  2022-02-23

  

  In principle, an ideal Fenton reaction element should have multiple oxidation states to form a redox cycle in the process of H2O2 decomposition to HO•. Although iron is very effective in catalyzing Fenton reaction, it requires a low pH value (pH 2-4) to reach the optimal catalytic efficiency, which

• br Experimental procedures br Results br Discussion The data

  2022-02-23

  

  Experimental procedures Results Discussion The data herein confirm the well documented neuroinflammatory effect of TLR3 activation following systemic administration of the viral mimetic poly I:C and the associated acute sickness response which includes fever, reduced body weight and allodyn

• Bile acids are the end products

  2022-02-22

  

  Bile acids are the end products of cholesterol catabolism and have also been considered as hepatomitogens. Recently, Yap has been shown to be activated by the mevalonate pathway, which is essential for the biosynthesis of isoprenoids and downstream cholesterol and bile acids (Sorrentino et al., 2014

• Given the overexpression of HO in some

  2022-02-22

  

  Given the overexpression of HO-1 in some tumors, such as CML, and its potential involvement in chemoresistance to classical chemotherapeutic agents, compounds 4 and 8f were tested in CML cell lines resistant to IM, a classical TK inhibitor used in CML. Compounds 4 and 8f, in combination with IM, sho

• Caspase Inhibitor Set I mg br Materials and methods br Resul

  2022-02-22

  

  Materials and methods Results Discussion Both EMT of the tubular epithelial Caspase Inhibitor Set I mg and the activation of fibroblasts are critical factors in the pathogenesis and progression of renal interstitial fibrosis. Accumulating evidence implicates EMT in the onset and pathogenes

• The Scribble complex localizes to the leading

  2022-02-22

  

  The Scribble complex localizes to the leading edge in response to integrin engagement. There, Scribble controls the activation Rac and PAK via the Rac GEF β-Pix (Bahri et al., 2010), which is required for collective cell migration (Omelchenko et al., 2014). However, on the rear edge, Scribble can be

• An interesting question is why RhoF has such the slow

  2022-02-22

  

  An interesting question is why RhoF has such the slow rate of GDP dissociation. The amino Epothilone B mutations in a presumable GDP-binding site of RhoF had only moderate effects on the GDP dissociation (Fig. 3C), which suggests a mechanism involving the global amino acid sequence of RhoF, rather

• br Introduction br Mitochondrial dysfunction and cancer

  2022-02-22

  

  Introduction Mitochondrial dysfunction and cancer Lactate and succinate as oncometabolites Intracellular actions of lactate and succinate as tumor promoters Cell-surface receptors for lactate and succinate and their role in cancer GPR109A as the receptor for butyrate and β-hydroxybu

• br Conclusions br Competing interests br

  2022-02-22

  

  Conclusions Competing interests Introduction Ethanol exposure has been linked to changes in the pattern of histone acetylation and deacetylation through histone acetyltransferases (HATs) and histone deacetylases (HDACs) in the Yeast Extract and in peripheral tissues, leading to ethanol depe

15722 records 469/1049 page Previous Next First page 上5页 466467468469470 下5页 Last page