• The repeat sequence TTAGGG of telomere could be

  2021-06-09

  

  The repeat sequence “TTAGGG” of telomere could be directly recognized by TERF1. TERF1 is indispensable for the maintenance of telomere Cyclopiazonic acid structure and integrity (Tan et al., 2017). Trf1 genetic depletion in vivo induces a persistent DNA damage response and telomere uncapping, which

• We continued to investigate the contribution of the EP

  2021-06-09

  

  We continued to investigate the contribution of the EP1 YM 58483 to nociceptive sensitization by utilizing its natural ligand PGE and tested the effect of local subcutaneous injection of PGE (5nmol in 5μl) into one hindpaw on mechanical and heat pain thresholds. Wild-type mice displayed maximum sens

• br Acknowledgements We thank Joseph Granger and Bryan Neuman

  2021-06-09

  

  Acknowledgements We thank Joseph Granger and Bryan Neumann for careful reading of this manuscript. This work is supported by NIH grants AG37609 and HL 60306 to TYC and CCYC. Introduction Eleven million tonnes of waste are produced yearly by the European pulp and paper industry (Monte et al.,

• There is evidence that the response

  2021-06-09

  

  There is evidence that the response of CYP450 activity to DEX is species-specific. CYP1A and CYP3A expressions were strongly induced by DEX in porcine hepatocytes (Rasmussen et al., 2014) and in rat and human, but not minipig or beagle dog hepatocytes (Lu and Li, 2001). Within fish, there are also s

• br Methods br Results br Discussion Skin

  2021-06-08

  

  Methods Results Discussion Skin biopsy and microneurography have both been described as useful tools in the diagnosis of PAN, directly identifying peripheral sympathetic fibers without the mediation of specific euk 134 organs (Donadio et al., 2005, Donadio et al., 2012a, Donadio and Liguor

• The kinase activity of DNA PKcs is essential

  2021-06-08

  

  The kinase activity of DNA-PKcs is essential for NHEJ, but the exact role of the enzymatic activity of DNA-PKcs plays in NHEJ is not fully understood [57]. In vitro, DNA-PKcs can phosphorylate each of the canonical NHEJ factors including Ku70/80 [58], [59], XRCC4 [60], [61], 7340 australia IV [62],

• In LPS treated BV cells

  2021-06-08

  

  In LPS-treated BV-2 cells, we found that the upregulated CysLT2R was translocated into the nucleus. The nuclear localization of CysLT2Rs in microglia has not been reported previously. It is known that CysLT1Rs in endothelial BIX 01294 translocated to the nucleus in a ligand-independent manner after

• Furthermore the Langerhans cell infiltrate in skin biopsies

  2021-06-08

  

  Furthermore, the Langerhans cell infiltrate in skin biopsies from RG7155-treated patients will be analyzed since keratinocyte derived IL-34 was identified as their survival factor (Greter et al., 2012). Microglia, the other macrophage population regulated by neural progenitor and glial cell-derived

• In general accurate results for the prediction of the solubi

  2021-06-08

  

  In general, accurate results for the prediction of the solubility in scCO2 + cosolvents using the CPA-EoS were verified. ALD values for each solute (Table 1) varied from 0.04 to 1.5. Few solutes, such as lauric acid, myristic acid, hydroquinone and salicylic acid, presented the highest ALD values. A

• RQ What are the different factors

  2021-06-08

  

  RQ2: What are the different factors that influence the decision to choose among different component origins? In total eleven factors grouped into three high-level themes that influence the decision to choose a component origin were identified. The project metrics factors are: time, cost, effort and

• Following the relationship model adopted in this work

  2021-06-08

  

  Following [20], [22], the relationship model adopted in this apoptosis inducer work to estimate the time to failure is the Inverse Power Law (IPL): Where L is the SUT life characteristic (e.g. the mean time to failure), s represents the stress level, while k and w are model-related parameters to be

• Interestingly Carver Johnson and Kim

  2021-06-08

  

  Interestingly, Carver, Johnson, and Kim (2016) investigated a polymorphism in the OPRM1 μ-opioid receptor gene for its role in sensitivity to social contexts. The G allele of this polymorphism was associated with higher levels of sensitivity. The authors found significant interactions, e.g. the nega

• br Conflicts of interest br Acknowledgements br Introduction

  2021-06-07

  

  Conflicts of interest Acknowledgements Introduction Atherosclerosis is the number one cause of death in the United States and among the leading causes of morbidity and mortality globally [1]. Inflammation is critical in all stages of atherosclerosis from the formation of a plaque in the ves

• br Application of D receptor PET in psychiatric disorders

  2021-06-07

  

  Application of D1-receptor PET in psychiatric disorders Discussion Compared to other markers of the DA system, only a limited number of studies have investigated D1-R in psychiatric disorders. In schizophrenia, which is the most studied condition with a total of 83 identified unique patients,

• The other interesting observation made during this

  2021-06-07

  

  The other interesting observation made during this study relates to the differences between the discrete IR-induced γH2AX foci and the robust H2AX phosphorylation observed during apoptotic DNA fragmentation. The pattern of H2AX phosphorylation observed during DNA fragmentation possibly reflects the

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