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Cyclin D inhibits the transcriptional activity of the transc
2020-05-26
Cyclin D1 inhibits the transcriptional activity of the transcription factors myogenin and MEF2 [39,40]. In addition, myogenin activates MEF2 expression, which feeds back to amplify the myogenin promoter [38]. In this study, DGKδ suppression, in addition to the increase of cyclin D1, inhibited myogen
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br Introduction In mammals there are ten known
2020-05-26
Introduction In mammals there are ten known isoforms of the enzyme diacylglycerol kinase (DGK), as well as gene splice variants. Enzymes of this family all have a homologous active site but differ widely in their molecular mass, mechanisms of activation and biological function (Shulga et al., 201
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br MCADD review br Funding None
2020-05-26
MCADD review Funding None. Introduction Bacteroides species are obligate anaerobes, Gram-negative, and non-spore-forming bacteria and 21 species of this genus are found particularly in the oral cavity and gastrointestinal tract in vertebrates [1,2]. B. fragilis is the most common Zafirluka
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Oral antipsychotics are substrates of CYP enzymes which are
2020-05-26
Oral antipsychotics are substrates of CYP450 enzymes, which are crucial to their metabolism and elimination (Fig. 1). The efficacy and toxicity of antipsychotic agents is affected by factors that induce or inhibit CYP450 expression and function, such as drug–drug interactions. Additionally, the mult
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In conclusion high methylation levels of
2020-05-26
In conclusion, high methylation levels of CDKL2 were observed both in HCC cell lines and tissues, which showed a negative association with mRNA expression. Moreover, treatment with demethylation agent in HCC cell lines could upregulate CDKL2 mRNA expression. The discovery of the epigenetic modificat
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In a previous study we reported
2020-05-26
In a previous study we reported that the systemic administration of the α1-adrenergic receptor antagonist prazosin attenuates the deficit in LY364947 reward function associated with precipitated nicotine withdrawal (Bruijnzeel et al., 2010). One of the aims of the present experiments was to investi
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Dopamine activity in the PFC and striatum may
2020-05-26
Dopamine activity in the PFC and striatum may be antagonistic, meaning that lower levels of dopamine in the striatum tend to correspond to higher levels of dopamine in the PFC and vice versa (Cools and D\'Esposito, 2011; Tunbridge et al., 2006). Human PET studies have reported that dopaminergic PFC
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An increased CK activity was found in septal
2020-05-26
An increased CK2 activity was found in septal neuronal Chrysin australia dissected from rat embryos after hypoglycemia [36]. These data indicated that CK2 activity is not only regulated by insulin but also by the glucose concentration. One essential step in insulin action is the binding of the hor
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Ageing is associated with increased
2020-05-25
Ageing is associated with increased reactive oxygen species (ROS) production, oxidative stress and oxidative damage [43,44]. Overproduction of ROS can impair endothelial function by suppressing NO synthesis and scavenging NO thereby decreasing its overall bioavailability. Moreover, sustained oxidati
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A robust meta analysis of randomized clinical
2020-05-25
A robust meta-analysis of 22 randomized clinical trials found that application of ischemic preconditioning strategies reduce ventricular arrhythmias [3]. Additionally, it was demonstrated that remote ischemic perconditioning (perRIC) induces immediate cardioprotection during ongoing ischemia by atte
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Early diagnosis of CVS and DCI is a key
2020-05-25
Early diagnosis of CVS and DCI is a key issue in the management of SAH patients. In this regard, CT Perfusion (CTP) is the most accurate and sensitive method for noninvasive imaging assessment of cerebral ischemia with a great value for prediction and early diagnosis of CVS and DCI. CTP is a relativ
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Our finding that activating DDR variants are a cause
2020-05-25
Our finding that activating DDR2 variants are a cause of this disease suggested that the ABL inhibitor dasatinib, a leukemia drug that also inhibits DDR2, could be used for treatment of affected individuals.10, 11 To examine the effect of dasatinib on p.Leu610Pro- and p.Tyr740Cys-induced autophospho
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KU55933 br RING dimerization RING type domains are found in
2020-05-25
RING dimerization RING-type domains are found in many different structural contexts. While many exist as single-chain KU55933 (Fig. 3A), a notable feature of RING-type E3s is their tendency to form homodimers and heterodimers (Fig. 3C–F). Homodimeric RING-type E3s include cIAP, RNF4, BIRC7 (shown
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In all available E E structures
2020-05-25
In all available E2:E3 structures, the RING-type domain binds the E2 on a surface that is remote from the active site Cys (and therefore from the ubiquitin thioester) (Fig. 2). The non-contiguous E3-binding and active sites on the E2 imply that the role played by a RING to facilitate ubiquitin trans
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Despite the fact that the precise relevance of
2020-05-25
Despite the fact that the precise relevance of Ube2E self-ubiquitination in vivo is still elusive, findings of Sarkari et al. do establish Ube2E1 ubiquitination in Finasteride sale [36]. In vivo self-ubiquitination of Ube2E1 is further supported by the high-throughput study aimed to identify all ub
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