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Because many growth factors function in a context
2018-11-12
Because many growth factors function in a context-dependent manner, we explored the effects of adding WNT3A to the MC on the growth of Bl-CFCs. In cultures containing a combination of hematopoietic growth factors (VEGF, SCF, IL-3, IL-6, thrombopoietin [TPO], EPO, and FLT3L), 0.2%–0.6% of cyp450 indu
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In this study we have described methods
2018-11-12
In this study we have described methods for the selective isolation of primitive hMSCs that may prove advantageous both experimentally and therapeutically. The identification of the combination marker LTV makes it possible to prospectively isolate functional hMSCs directly from BM. Using these cells
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The model of this current study showed that CD
2018-11-12
The model of this current study showed that CD133 and CD24 markers, as a single or combined expression, are so promiscuous that they are not able to identify a pure population of adult renal stem cells. In PKHhigh cells, the only cell population presenting self-renew and an in vitro multipotency cap
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Oncolytic adenoviruses seem like ideal candidates to target
2018-11-12
Oncolytic adenoviruses seem like ideal candidates to target cancer initiating cells because they are cytotoxic and are not subject to the typical mechanisms of drug resistance, such as drug efflux pumps and defective apoptotic signaling. Indeed, studies with oncolytic adenoviruses in breast and 4 me
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The effects of TLQP on neurogenesis
2018-11-12
The effects of TLQP-62 on neurogenesis are thus similar to what is reported for antidepressant fluoxetine and serotonin (5-HT), both of which increase the proportion of undetermined Type 2a NPCs marked by Nestin+ and DCX-immunostaining and lacking the radial glial-like morphology (Boku et al., 2011;
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We show that the PB transposon and its
2018-11-12
We show that the PB transposon and its transposase are functional and quite efficient in terms of stable gene transfer to primary mesoangioblasts when compared to the transfection of plasmid vectors. Transposition occurred even when using large transposons comprising two expression cassettes and a s
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Finally we provide molecular evidence for PB transposase act
2018-11-12
Finally, we provide molecular evidence for PB transposase activity in vivo after plasmid intramuscular injection and electrotransfer of the murine muscles, for instance from the recovery and sequencing of several transposon–genomic junctions. Interestingly, such integration events were not able to m
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Recently several studies have suggested that peripheral bloo
2018-11-09
Recently, several studies have suggested that peripheral blood mononuclear protease inhibitors (PBMCs) are a promising resource for generating iPSCs because most of these cells do not undergo TCR rearrangement (Loh et al., 2010; Mack et al., 2011; Seki et al., 2010). However, PBMCs are composed of s
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Our findings directly interface with the role of CXCL SDF
2018-11-09
Our findings directly interface with the role of CXCL12 (SDF1)/CXCR4 signaling in adult HSPC migration: CXCL12 levels increase in response to stress and inflammation, and influence HSPC mobilization and extravasation within the adult BM (Dar et al., 2006). As hematopoietic niches are hypoxic during
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br Acknowledgment br This work was supported
2018-11-09
Acknowledgment This work was supported by the Ministry of Science and Education of the Russian Federation (Program 3.329.2014/K). According to Kotelnikov\'s works , normal fluctuation noise consists of a large number of pulses following each other in random time intervals; it UM 171 is also
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abiraterone acetate Outline Interoception is described as th
2018-11-09
Outline Interoception is described as the perception of the internal state of one’s body; as such, signals including those relating to hunger, temperature, heart rate, and blood sugar levels are all interoceptive in nature. These bodily signals are thought to be represented within the insula and an
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Most studies have been focused on investigating the molecula
2018-11-09
Most studies have been focused on investigating the molecular control of GPCR ubiquitination by identifying the E3 ubiquitin ligase, while the little information is available for deubiquitination of GPCR by deubiqutinating enzymes. Here we report that a deubiquitinating enzyme, USP11, promotes LPA1
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The detection of ODC derived DeMeth
2018-11-09
The detection of ODC-derived DeMeth MOG-DNA in the cuprizone mouse model lead us to examine the methylation state of the MOG gene in human DNA. Analysis of an evolutionarily conserved region of MOG-DNA in human brains and liver showed an identical demethylation pattern in CpG dinucleotides also pres
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br Funding Source This study was funded by Mesoblast Inc
2018-11-09
Funding Source This study was funded by Mesoblast, Inc. Contributors Declaration of Interests Prior Presentation Acknowledgements Introduction In 1933, Henrik Sjögren, in his doctoral dissertation introduced the neologism, keratoconjunctivitis Sicca (Murube, 2010, Sjögren, 1933).
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thiostrepton The authors identified other genetic variants t
2018-11-09
The authors identified 13 other genetic variants that are promising candidates. None of these additional genetic variants reached the pre-specified level of statistical significance and therefore do not meet the discovery threshold but remain as promising candidates requiring further work and valida
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