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Induction of EndMT results from integration of multiple extr
2018-11-08
Induction of EndMT results from integration of multiple extrinsic inputs within the dynamically shifting cellular environment of cardiogenesis. Owing to the membrane bound presentation of ligands, Notch signaling status is dependent on the organization and distribution of signal-presenting and signa
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hippo pathway br Materials and methods br Author disclosure
2018-11-08
Materials and methods Author disclosure statement Acknowledgments This study was supported by fund from National Medical Research Council (NMRC) of China to SZ (fund number: 30400447) and HW (fund number: 30500548). Resource table. Resource details To engineer a biallelic mutation in t
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Further support for the hierarchical
2018-11-08
Further support for the hierarchical two-stem-cell model came with the discovery of an additional reserve ISC marker locus, Hopx, encoding an atypical homeodomain protein with functions in early heart development (Chen et al., 2002). An IRES-CreERT2 cassette inserted into the endogenous Hopx locus r
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eukaryotic initiation factor In their letter Sadek et
2018-11-08
In their letter, Sadek et al. refer to other studies showing robust and reproducible regeneration. However, none of the studies published to date (Haubner et al., 2012; Heallen et al., 2013; Jesty et al., 2012; Naqvi et al., 2014; Strungs et al., 2013) actually performed apex resection on postnatal
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atp citrate lyase inhibitor br Results br Discussion hESCs d
2018-11-08
Results Discussion hESCs demonstrate the potential to serve as a starting cell population for bone regeneration, and previous studies report effective differentiation of hESCs to osteogenic lineage (Arpornmaeklong et al., 2010; Kärner et al., 2009). However, it remains important to better defi
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br Specification of the mammalian germ
2018-11-08
Specification of the mammalian germ cell lineage is an inductive process In model organisms such as Drosophila, C.elegans, Xenopus and Danio (zebrafish), PGCs are created each generation through a process known as pre-formation. This is a process driven by RNAs and proteins inherited from the ooc
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Most remarkably we identified Nppb Bnp a well
2018-11-08
Most remarkably, we identified Nppb (Bnp), a well-studied marker in cardiovascular disease, as a novel putative Shox2 target gene. This gene was analyzed as working myocard marker and turned out to be significantly upregulated in Shox2 SAN-like order Myriocin and in right atrial tissue of Shox2-KO
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Embryonic stem cell protocols frequently employ irradiated M
2018-11-08
Embryonic stem cell protocols frequently employ irradiated MEFs as feeder cultures (Conner and fibroblast, 2001). We plated mouse embryonic stem (ES) PCI32765 either with or without feeders and compared ALP expression in both cultures using our multiplexed luminescence method. Higher levels of ALP w
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br Results br Discussion Our studies highlight
2018-11-08
Results Discussion Our studies highlight the potential clinical significance of the iC9 safeguard system. Recent studies introducing suicide gene-based safeguard systems into mouse or rhesus iPSCs report that teratoma formation was significantly delayed or inhibited only when treatment started
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br Introduction For more than
2018-11-08
Introduction For more than a decade, multipotent stem bmn 673 have been extensively studied for various cardiovascular diseases such as heart failure and ischemic cardiomyopathy, which was defined as the “first-generation” cell therapies (Behfar et al., 2014). The “next-generation” cell therapie
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Finally an important practical implication
2018-11-08
Finally, an important practical implication of our data is that both fibroblasts and blood can be used for the generation of comparable iPSC lines for large-scale biobanking purposes (Figure 6). Our results demonstrate that variability among small cohorts of iPSCs may lead to erroneous conclusions (
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The most commonly used trophoblast markers reported in
2018-11-08
The most commonly used “trophoblast” markers reported in the literature are cytokeratin 7 (KRT7), HLA-G, and human chorionic gonadotropin (hCG), but these are either not specific to all trophoblast integrin inhibitors or are expressed in other cell types. Several of the transcription factors (TF) t
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Our study made use of single cell
2018-11-08
Our study made use of single-cell transcriptional profiling to define the heterogeneity of hormone-producing Sulfo-NHS-Biotin derived from hPSCs. The technology is a powerful tool that allowed us to determine the percentage of various hormone-producing cells and shifts in this distribution upon trea
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In summary we have generated a stable e
2018-11-07
In summary, we have generated a stable, expandable human NSC line (LM-NSC008) by overexpression of the L-MYC gene. We have characterized the LM-NSC008 cell line in vitro and in vivo. Our findings demonstrate the potential therapeutic utility of LM-NSC008 NSC 74859 for therapeutic drug delivery to C
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glycogen phosphorylase We did not observe an increased
2018-11-07
We did not observe an increased number of ubiquitin IBs in neurons derived from an isogenic iPSC line with a classical premutation length. It is likely that the expression of mRNA with longer CGG repeat lengths in UFM neurons results in accelerated pathological development compared with premutation
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