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vivo vu Originally identified as a GPCR upregulated
2021-10-13
Originally identified as a GPCR upregulated on Burkitt lymphoma cells upon Epstein-Barr virus infection (Birkenbach et al., 1993), Ebi2 was later found to play critical roles in immunity by regulating the migration of activated vivo vu to extrafollicular sites for early plasmablast responses (Gatto
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wehi Studies dealing with the effects of ischemia
2021-10-13
Studies dealing with the effects of ischemia on EAATs have been previously reported, but some discrepancies in literature appear between them probably as a consequence of the different models, species, time of reperfusion after ischemia and age of the animals. Thus, in human, wehi stroke-dependent i
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Recent studies suggested that non coding RNAs
2021-10-13
Recent studies suggested that non-coding RNAs participate in the modulation of Glut1 expression. For instance, the lncRNA NBR2-Glut1 axis was suggested to modulate cancer cell sensitivity to phenformin [37]. In renal carcinoma, miR-1291 is involved in the regulation of Glut1 PCI-34051 [38]. Therefor
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Various strategies have been pursued in
2021-10-13
Various strategies have been pursued in the search for GIPR antagonists. Antibodies raised against both GIP(1–42) [14], [15] or the GIPR [16], [17], a small molecule antagonist [18], amino Paxilline mg substitutions of GIP(1–42) [19], and various GIP(1–42) truncations and modifications such as e.g.
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The caseins are a family of milk
2021-10-13
The caseins are a family of milk phosphoproteins whose biological function is to provide supersaturating concentrations of calcium, phosphates, and essential LY 255283 to the neonate (Vonderhaar and Ziska, 1989). α- and β-caseins, the most abundant of the milk caseins, are described as calcium sens
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G quadruplex DNA structures may exist in either
2021-10-12
G-quadruplex DNA structures may exist in either positive or negative strand of a promoter to regulate gene expression. The positive strand of the HOXC10 promoter is overall C-rich in the 1000 bp upstream of the TSS (36.6% of C versus 24.1% of G) and contains many C-runs; thus, G-quadruplex structure
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Of the cases identified herein three known and
2021-10-12
Of the 52 cases identified herein, three known and 11 novel FGFR fusion partners were identified. Notably, an oligomerization domain, including coiled-coil dimerization domains similar to that seen in echinoderm microtubule associated protein like 4 gene (EML4), which is the most common ALK partner
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Poziotinib br Drug design Over the past decades the
2021-10-12
Drug design Over the past decades, the development of synthetic, direct fXa inhibitors has undergone four phase. Although these fXa inhibitors possess various scaffolds, most of them bind to the active site in a characteristic l-shaped conformation. In other word, they have a three-component syst
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Finally the optimized leads and were tested in rat
2021-10-12
Finally, the optimized leads (−)- and (−)- were tested in rat model of CIPN (3 and 30 mg/kg, po, qd, administered for 7 days) and the results have been shown in . Under acute set up, after single oral administration at 30 mg/kg, both the compounds exerted significant improvement of the NP condition
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br Acknowledgments The breast cancer laboratory is supported
2021-10-12
Acknowledgments The breast cancer laboratory is supported by the Australian National Health and Medical Research Council (NHMRC) grants no. 1016701, no. 1024852, no. 1086727; NHMRC IRIISS; the Victorian State Government through VCA funding of the Victorian Breast Cancer Research Consortium and Op
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br Acknowledgments The breast cancer laboratory is supported
2021-10-12
Acknowledgments The breast cancer laboratory is supported by the Australian National Health and Medical Research Council (NHMRC) grants no. 1016701, no. 1024852, no. 1086727; NHMRC IRIISS; the Victorian State Government through VCA funding of the Victorian Breast Cancer Research Consortium and Op
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4-P-PDOT synthesis We notice that previous reports of arseni
2021-10-12
We notice that previous reports of arsenic exposure are not completely consistent with each other, in terms of exposure-changed histone acetylations. In an early investigation, As exposure (7.5 μM) of HepG2 4-P-PDOT synthesis increased H3K9ac after 24 h, when analyzed by methods of immunofluorescenc
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Aberrant expression of HKII may be a
2021-10-12
Aberrant expression of HKII may be a required feature for cancer development and progression. Overexpression of HKII has been reported in tumor tissues of cancer patients with liver [9], ovary [8], [24] and larynx [25]. The clinical significance of HKII in cancer was noted as overexpression of HKII
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Nevertheless the frequency of CTCs was higher in patients
2021-10-12
Nevertheless, the frequency of CTCs was higher in patients with metastatic breast cancer, which is to be expected because cancer Cdk2/Cyclin Inhibitory Peptide I from the original clone that caused the metastasis probably had features favoring their spread throughout the body. When we take HER2+ CTC
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neuropeptides Mapping PPI networks is challenging as it is d
2021-10-12
Mapping PPI networks is challenging, as it is difficult to express and purify large variaties of neuropeptides in sufficient quantities to allow the study of interactions between them. Membrane-bound proteins are particularly difficult to purify in functional form due to their amphiphilic nature. F
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