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Under optimized assay conditions very low
2020-01-25
Under optimized assay conditions, very low concentrations (20pM) of [125I]YP20 bound to hCRF1-CHO Estradiol 17-(β-D-Glucuronide) sodium salt synthesis membranes with high specificity (>95% inhibited by 1μM astressin) and in a membrane protein-dependent manner. Specific binding was selective vs. the
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Interestingly from our consensus SBVC protocol only few comp
2020-01-25
Interestingly, from our consensus SBVC protocol only few compounds (less than 150) have been scored with a full ‘ consensus’. That means that these compounds appear in the top 5% of the database when ranked by every scoring function independently. After visual inspection, we have realized that two a
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Previous studies have documented that
2020-01-25
Previous studies have documented that SCFAs may elicit effects on lipid metabolism via de novo synthesis and transport. Acetate is not only used as an energy source, but is also constituted as a substrate for the cholesterol synthesis in the liver through acetyl-CoA, thus affecting plasma cholestero
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It was reported that IVM modulates various ion channels
2020-01-25
It was reported that IVM modulates various ion channels, such as type-A GABACls, α7 acetylcholine-gated cation channels, P2X4 ATP-gated cation channels, and glycine-gated chloride 1,3-PBIT dihydrobromide receptor in vertebrates (Adelsberger et al., 2000, Khakh et al., 1999, Krause et al., 1998, Krů
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Although CCR expression clearly identifies
2020-01-25
Although CCR6 expression clearly identifies MBC precursors within the GC, we found that the expression of this chemokine receptor by responding Kaempferol-3-rutinoside was not required for MBC differentiation and had no detectable impact on the GC subsets analyzed in this study. Although this is in
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br Acknowledgments We thank our colleagues
2020-01-25
Acknowledgments We thank our colleagues who have contributed to our understanding of the IGF-1, human recombinant and the structure and function of APC/C, and apologize to those whose work we were unable to cite here. We thank J. Rajan Prabu for making the movies showing APC/C conformational cha
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Dapivirine In all available E E
2020-01-25
In all available E2:E3 structures, the RING-type domain binds the E2 on a surface that is remote from the active site Cys (and therefore from the ubiquitin thioester) (Fig. 2). The non-contiguous E3-binding and active sites on the E2 imply that the role played by a RING to facilitate ubiquitin trans
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However a two receptor model presents a mystery of how
2020-01-25
However, a two-receptor model presents a mystery of how MBns know whether they are receiving an acquisition or forgetting signal from the PPL1 DAns. The most attractive explanation for this is that the two receptors might have different signaling properties and mobilize distinct signaling cascades.
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Introduction PGE is a major mediator present at sites
2020-01-25
Introduction PGE2 is a major mediator present at sites of inflammation [1]. It is well established that PGE2 contributes to the localized and systemic symptoms of inflammation. A key study by Portanova et al. [2] demonstrated that anti-PGE2 Prednisolone were able to reverse the swelling and pain i
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br Oxidoreductase like MEM for prodrug activation br Future
2020-01-25
Oxidoreductase-like MEM for prodrug activation Future outlook Although MEM-mediated prodrug activation has been performed by different MEMs and prodrugs, and their effectiveness have been proved in vivo, only a few types of MEMs or prodrugs have been explored in prodrug activation until now [2
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Biochemically the primary function of PPIP
2020-01-25
Biochemically, the primary function of PPIP5K2 is 1-kinase-mediated phosphorylation of 5-IP7 to form 1,5-IP8 (Shears, 2018). To a lesser extent, PPIP5K2 also phosphorylates IP6 to produce 1-IP7. Furthermore, PPIP5K2 has been shown to catalyze a reverse reaction, that is, dephosphorylation of 1,5-IP8
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Imatinib STI is a first line tyrosine kinase inhibitor TKI
2020-01-25
Imatinib (STI-571) is a first-line tyrosine kinase inhibitor (TKI) targeted at breakpoint cluster region-Abelson kinase (ABL) for the treatment of chronic myeloid leukemia (CML) [26]. As a type II inhibitor, imatinib achieves significant selectivity by binding to an inactive DFG-out conformation (DF
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(+)-Usniacin receptor In addition to demonstrating the impor
2020-01-25
In addition to demonstrating the importance of DNMTs, we show that TGFβ1 differentially regulated DNMTs, and that TGFβ1 is both necessary and sufficient to induce lineage conversion of hepatocytes into MLCs with phenotypes and multipotency resembling MSCs. Upon withdrawal of TGFβ1 on day 28, we obse
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Finally this study described that the lead compound
2020-01-25
Finally, this study described that the lead EPZ-6438 (1) acted as an efficient alkylating agent for the G4 structure in addition to the previously reported T-T mismatch structure. The shortcoming of probe (1) is the lack of a structure selectivity, but that can be overcome by changing the acridine s
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For this reason downstream components of the
2020-01-23
For this reason, downstream components of the inflammatory pathway have been investigated in the search for alternative targets. Targeting such downstream elements might result in safer and more tolerable analgesics. PGE mediates its effects through binding to four G-protein-coupled receptors (EP1-4
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