• br Introduction Adenosine deaminase ADA which can

  2024-05-18

  

  Introduction Adenosine deaminase (ADA), which can catalyze the conversion of AD to inosine by removing an amino group, is a key hydrolytic enzyme of purine metabolism (Conway and Cooke, 1939), and plays an important role in an amount of diseases. For example, an increase of ADA activity in serum

• br Perspectives Given the complexity of the cellular interac

  2024-05-18

  

  Perspectives Given the complexity of the cellular interactome and of protein scaffolding, further progress in revealing how individual membrane proteins, including APP and AChE, interact with each other at various levels, from cell-surface shedding to gene regulation, will clarify some intrinsic

• NSAIDs induce gastrointestinal toxicity and evoke

  2024-05-18

  

  NSAIDs induce gastrointestinal toxicity and evoke motilin receptor by decreasing the production of gastroprotective prostanoids and by redirecting the COX substrate AA into LT biosynthesis, thereby causing vasoconstriction in gastric mucosa and airways (Celotti and Laufer, 2001; Koeberle and Werz,

• The mechanism by which Gas

  2024-05-18

  

  The mechanism by which Gas6 prevents inflammation has been reported to be via inhibition of Toll-Like receptors (TLRs) signaling (Cui et al., 2016). After injury, TLRs become stimulated, leading to downstream activation of TRAF3 and TRAF6 and translocation of several transcription factors, such as I

• br Materials and methods br Results br Discussion The succes

  2024-05-18

  

  Materials and methods Results Discussion The success of CAR-T cell therapy is based on two major facts: one is that cancer cells express tumor-associated antigens (TAAs) on their surface that can be detected by the human immune system; the other is that the CAR molecules target these TAAs o

• br Concluding Remarks and Future Directions The physiologica

  2024-05-18

  

  Concluding Remarks and Future Directions The physiological significance of autophagy in neuronal function is steadily emerging. The studies discussed herein reveal that key neuronal functions, such as neurotransmitter release, pruning of dendritic spines, and behavioural outputs of neural network

• br Introduction In addition to ATP production an important

  2024-05-18

  

  Introduction In addition to ATP production, an important role of mitochondria in the pancreatic beta cell is anaplerosis, which is the net synthesis of citric IKK Inhibitor VII receptor cycle intermediates that are exported to the cytosol where they are converted to numerous other metabolites th

• br Disclaimer Statement br Acknowledgments br Introduction M

  2024-05-18

  

  Disclaimer Statement Acknowledgments Introduction Metabolic changes are a common feature of cancerous tissues. Mutations in oncogenes and tumor suppressor genes cause alterations to multiple intracellular signaling pathways that rewire tumor cell metabolism and re-engineer it to allow enhan

• Another contributor for the G M arrest in A and

  2024-05-18

  

  Another contributor for the G2/M arrest in A549 and H1299 cells might be p21WAF1/CIP1 which was up-regulated upon ovatodiolide treatment. p21WAF1/CIP1 is a common CDKs inhibitor which blocks Ridaforolimus G2/M phase progression in various types of cancer cells (Kim et al., 2015, Liberio et al., 2015

• The amino hydroxy methyl isoxazolepropionic acid AMPA recept

  2024-05-18

  

  The α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic AVL-292 (AMPA) receptor is also enriched in postsynaptic striatal neurons (Bernard et al., 1997, Kondo et al., 2000, Reimers et al., 2011). Its activity is subjected to the regulation by a mechanism involving phosphorylation (Lu and Roche, 2012).

• br Roles of apelin and APJ in cardiovascular diseases br

  2024-05-18

  

  Roles of apelin and APJ in cardiovascular diseases Therapeutic potential of apelin/APJ in cardiovascular diseases Since the apelin/APJ system plays a key role in the occurrence and development of cardiovascular diseases, it seems logical to presume that targeting this axis should be feasible a

• br Consequences of central apelin APJ modulation Regarding

  2024-05-18

  

  Consequences of central apelin/APJ modulation Regarding extra-hypothalamic actions, recent data demonstrate that the central apelin/APJ system could be a potential new target for the regulation of memory (Han et al., 2014). Then, intracerebroventricular (icv) apelin administration in mice impairs

• br Brain Angiotensin II receptors The information above leav

  2024-05-17

  

  Brain Angiotensin II receptors The information above leaves Angiotensin II receptors as the only RAAS components for which localization, regulation of expression and function in the pth hormone synthesis has been convincingly demonstrated, with the use of quantitative film and emulsion autoradio

• br Conclusions br Material and methods br Conflicts of inter

  2024-05-17

  

  Conclusions Material and methods Conflicts of interest Acknowledgements Introduction Currently more than 30 human proteins are implicated in a range of degenerative disorders owing to their misfolding and misassembly into various aggregate structures and leading to at least 20 serious

• Asparagine synthetase ASNS is a glutamine amidotransferase t

  2024-05-17

  

  Asparagine synthetase (ASNS) is a glutamine amidotransferase that catalyzes ATP-dependent synthesis of asparagine and glutamate from aspartate and glutamine. Upregulation of ASNS expression renders leukemia cells resistant to l-asparaginase treatment, and ASNS is essential for cell survival in the a

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