• DDR is widely expressed in

  2020-07-27

  

  DDR1 is widely expressed in several tissues (Alves et al., 1995, Curat & Vogel, 2002, Ferri et al., 2004, Hou et al., 2001, Mohan et al., 2001, Sakamoto et al., 2001, Tanaka et al., 1998) including the mouse (Bhatt et al., 2000, Franco-Pons et al., 2009, Sanchez et al., 1994, Seo et al., 2008, Zerli

• The IL family is also named the

  2020-07-27

  

  The IL-2 family is also named the γ-chain (γc) family because the receptors for these cytokines share γc (also known as IL-2Rγ and CD132), which consists of IL-2, IL-4, IL-5, IL-7, IL-9, IL-15 and IL-21 [21]. Both circulating IL-2 and aortic IL-2 receptor are reported to increase in type A AD when c

• br Discussion This study is the first analysis

  2020-07-27

  

  Discussion This study is the first analysis of the transcriptome of drought-stressed soybean crown nodules. Previously, only the transcriptome of developing non-stressed crown nodules has been investigated (van Wyk et al., 2014). In our study drought stress decreased soybean plant growth but resu

• Overall our results indicate that the cutaneous HPV

  2020-07-27

  

  Overall, our results indicate that the cutaneous HPV8 E7 oncoprotein has a leucine rich NES (76IRTFQELLF84) within the zinc-binding domain that interacts with CRM1 export receptor and mediates its nuclear export. We have previously shown that the mucosal low risk HPV11 E7 has a leucine-rich NES (76I

• Based on the finding described above the present study

  2020-07-27

  

  Based on the finding described above, the present study was designed to investigate the effects of specific CRF receptors, CRF1 and CRF2, in the BLA and CeA on the duration of TI in guinea pigs (Cavia porcellus). To this end, we evaluated whether administration of the CRF1 Wortmannin antagonist CP-

• Using characteristic features of ECM proteins and a computat

  2020-07-27

  

  Using characteristic features of ECM proteins and a computational pipeline combining interrogation of protein and gene databases, we previously defined the matrisome as the ensemble of ECM and ECM-associated proteins [[16], [17], [18]]. In mammals, the matrisome represents 4% of the genome, or appro

• CysLTs trigger contractile and inflammatory processes throug

  2020-07-25

  

  CysLTs trigger contractile and inflammatory processes through the specific interaction with cell surface receptors belonging to the rhodopsin family of the G protein-coupled receptor (GPCR) genes. Until now, two receptor subtypes have been cloned, namely CysLT1 and CysLT2[8]. In particular, when the

• Sixty eight male Sprague Dawley rats were acquired from

  2020-07-25

  

  Sixty-eight male Sprague–Dawley rats were acquired from the University of South Dakota Laboratory Animal Services (Vermillion, SD, USA) and housed in pairs at 22°C (60% relative humidity) on reverse 12h light/dark Laminin 925-933 (dark cycle started at 10:00a.m.) with food and water freely accessib

• Wu et al explored the anti inflammatory

  2020-07-25

  

  Wu et al. explored the anti-inflammatory mechanisms by which osthole 35 acted on HepG2 cells cultured in a differentiated medium from cultured 3T3-L1 preadipocyte cells. HepG2 cells, a human liver cell line, were treated with various concentrations of osthole 35 in differentiated media from cultured

• In humans individual differences in prefrontal dopamine are

  2020-07-25

  

  In humans, individual differences in prefrontal dopamine are partially caused by the Val158Met single-nucleotide polymorphism on the catechol-O-methyltransferase gene (COMT). This gene controls activity of the COMT enzyme, which degrades extracellular catecholamines including dopamine. The Val varia

• However not all inhibitory profiles by

  2020-07-25

  

  However, not all inhibitory profiles by metals can be a priori considered artifacts of the methodology used to quantify the activity of such enzymes. Metals can indeed interfere with cholinesterases, and the mechanisms are varied. The inhibitory effect of specific metals may derive from their abilit

• br Results br Discussion Here we establish a key

  2020-07-25

  

  Results Discussion Here we establish a key kinase cascade that acts at PCs to promote homolog pairing and synapsis. CHK-2 phosphorylates the zinc finger proteins that specify PCs, which, in turn, primes their recruitment of PLK-2 (Figure 7D). By recruiting these two kinases, PCs serve as signa

• Studies using SERPINB deficient mice established the signifi

  2020-07-25

  

  Studies using SERPINB1-deficient mice established the significant role for SERPINB1 in protecting lung antimicrobial proteins from proteolysis during microbe infection and its regulatory role in sustaining the balance of neutrophil reserve [15]. Neutrophil serine proteases (NSPs) (elastase, cathepsi

• br Materials and methods br Results br Discussion

  2020-07-25

  

  Materials and methods Results Discussion GOS potently inhibited SRD5A1 in COS-1 cells (Fig. 4A) and rat Leydig cells (Fig. 4B), possibly attenuating testosterone activation into DHT. It has been reported that gossypol inhibited human SRD5A1 with IC50 of 7 × 10−6 M [28]. Interestingly, gossy

• In summary our findings indicate that bFGF

  2020-07-25

  

  In summary, our findings indicate that bFGF stimulates CPT1 expression, FA oxidation and lactate production with the participation of PPARβ/δ activation. On the other hand, this investigation shows that FSH concomitantly regulates the expression of genes involved in FA metabolism and in mitochondria

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