• Roughly years have gone by

  2019-04-22

  

  Roughly 15 years have gone by since the identification of the main characters involved in the interplay of the RANK–RANKL system. This gave rise to the race for elucidating their biological role . In those years, in vivo silencing experiments for both Receptor Activator of Nuclear Factor κ B (RANK)

• enkephalin cost The participants discussed several overarchi

  2019-04-22

  

  The participants discussed several overarching themes, concluding that research is too often separate from implementation. A crucial gap remains between the development of efficacious health interventions and their optimum delivery in real-life settings. This gap is particularly true in many low-inc

• PXD101 br Al hablar del requisito sine qua

  2019-04-22

  

  Al hablar del requisito sine qua non de conocer la lengua uitoto, vale la pena hacer un paréntesis para repasar el estado de los estudios propiamente lingüísticos. Diferentes recuentos bibliográficos sobre las fuentes para el estudio de las lenguas de la Amazonia colombo-peruana, reportan que los

• br Identidade negra e quilombola

  2019-04-22

  

  Identidade negra e quilombola O uso da expressão “remanescentes” para classificar os agrupamentos negros, enquanto unidades que guardam correspondência histórica com os quilombos, motivou reflexões sobre seu significado. Adotamos o entendimento de que ao contrário do sentido de sobra ao qual pode

• mth1 pathway There was a modest excess risk

  2019-04-22

  

  There was a modest excess risk of mortality associated with multidrug-resistant organisms, which was lower than that previously recorded in south Asia. There are methodological challenges in the attribution of excess neonatal mortality with antimicrobial resistance because of known confounding with

• Estimates of life expectancy are of

  2019-04-20

  

  Estimates of life expectancy are of obvious importance to people with HIV-1, and are essential to monitor and predict the progress of the HIV/AIDS epidemic and to plan health services. The Rwandan study reported by Sabin Nsanzimana and colleagues in is the first from sub-Saharan Africa to focus on t

• With the publication of this month

  2019-04-20

  

  With the publication of this month\'s issue, we mark \'s first birthday. I hope you will allow me to effuse for a moment in the manner of a new parent discovering the fascination of her offspring\'s everyday achievements… Since its conception in March, 2013, the infant has maintained a healthy int

• mmae Real time quantitative polymerase chain reaction

  2019-04-20

  

  Real-time quantitative polymerase chain reaction (RQ-PCR) was performed to quantify BCR/ABL1 transcript as described previously [1]. The quantitative results were expressed as percent ratios relative to an ABL1 internal control using the following formula (p210 BCR–ABL/ABL1×100×CF) [2]. The level of

• TAPI-1 Prior case reports have described hematological remis

  2019-04-20

  

  Prior case reports have described hematological remission in patients with myelofibrosis during treatment with bisphosphonates, but a phase II study investigating the effects of zoledronic TAPI-1 on patients with myelofibrosis showed responses in only 1 of 16 patients[13]. In conclusion, we report

• In an earlier study we used a

  2019-04-20

  

  In an earlier study, we used a questionnaire to assess musculoskeletal pain in patients with CML who had achieved DMR (MR4.0) and discontinued TKI treatment, including IM, nilotinib, and dasatinib [5]. Nine out of the 27 patients surveyed developed musculoskeletal pain after discontinuing TKIs. In

• Rapalink-1 br Authorship br Conflict of interest br Acknowle

  2019-04-19

  

  Authorship Conflict of interest Acknowledgments The Leukemia & Lymphoma Society supported CRC with a Scholar in Clinical Research award (2400-13). This work was supported by the Gatorade Trust from the University of Florida Department of Medicine. Introduction Klinefelter syndrome (KS),

• olmesartan medoxomil br Hematopoietic cell transplantation H

  2019-04-19

  

  Hematopoietic cell transplantation HCT is generally recommended for AML patients with intermediate or high risk cytogenetics, when the aim of treatment is curative. However, elderly patients are seldom offered a transplant mainly due to concerns regarding toxicity, despite the fact that the main

• br In the cluster randomised

  2019-04-19

  

  In the cluster randomised controlled trial by Marcel Yotebieng and colleagues (August, 2015) the addition of Step 10 of the UNICEF Baby Friendly Hospital Initiative (BFHI)—that is, the provision of additional support for breastfeeding—did not enhance the effects of steps 1–9, and may even have les

• br Materials and methods br Results br Discussion

  2019-04-19

  

  Materials and methods Results Discussion The data in the present study showed that ABZ induces SIRT3 downregulation and SIRT3 overexpression attenuates the microtubule-destabilizing effect of ABZ in U937 cells. In agreement, previous studies have revealed that SIRT3 overexpression inhibits

• Introduction Atrial fibrillation AF is a highly

  2019-04-19

  

  Introduction Atrial fibrillation (AF) is a highly prevalent atrial arrhythmia that affects approximately 10% of individuals older than 75 years of age and tends to increase in prevalence with advancing age [1–3]. Although AF itself is not life threatening, it is a risk factor for stroke, and the AF

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