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Several in vivo and in vitro studies have demonstrated chang
2024-09-10
Several in vivo and in vitro studies have demonstrated changes in bioactive lipid profiles under hyperglycemic conditions and have linked these changes with increased leukocyte adhesion and vascular dysfunction during diabetes. This input has originated partly from lipidomic studies that showed elev
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L-Glutathione Reduced br Steroidogenesis in the skin The syn
2024-09-10
Steroidogenesis in the skin The synthesis of steroid hormones takes place in many tissues of which the adrenal glands, ovaries, testis, placenta and L-Glutathione Reduced are considered to be classical steroidogenic organs. Nevertheless, skin constitutes an important peripheral steroidogenic tiss
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Expression of Twist and the AR
2024-09-10
Expression of Twist1 and the AR are increased by oxidative stress, but the change in the receptor (mRNA/protein) is lost after treatment with siRNAs that target Twist 1 (Shiota et al., 2010). Twist 1 was found to bind to E-boxes, 5′-CANNTG-3′, in the proximal promoter (−442 to +51 bp) and upstream r
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beta-Nicotinamide mononucleotide receptor There is a growing
2024-09-10
There is a growing body of evidence showing that pentobarbital causes memory disorders [3], [4], [5]. Our results that a single injection of pentobarbital into bilateral hippocampus significantly impaired hippocampus-dependent spatial memory retrieval (Fig. 1) add support to that evidence. Previous
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The preferential expression of ALOX
2024-09-10
The preferential expression of ALOX15B in human macrophages may explain why human genetic studies investigating the association of ALOX15 with cardiovascular disease did not show consistent results. Two rare functional polymorphisms have been characterized in the ALOX15 gene, which leads to increase
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This study demonstrates numerical alterations of creatinine
2024-09-10
This study demonstrates numerical alterations of creatinine levels potentially reflecting ongoing or even higher myocardial contraction of the LAA after successful LAAC. Creatinine is the direct breakdown product of creatine in muscle, the key metabolite for energy supply during muscular and myocard
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Blocking the action of CREB with the C
2024-09-10
Blocking the action of CREB with the C646 inhibitor together with increasing Akt activation with the SC79 agonist is particularly interesting as it significantly reduced wound closure time from 7 days (which is required for complete closure of control hTECs exposed to DMSO) to only 4 days (when hTEC
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br Introduction Several studies have found that hypothalamic
2024-09-10
Introduction Several studies have found that hypothalamic Akt-mediated signaling pathways play critical roles in the regulation of food intake and PD-1/PD-L1 Inhibitor 3 metabolism in mammals [[1], [2], [3], [4], [5], [6]]. Central injections of the inhibitor of phosphoinositide 3- kinases (PI3
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Kenpaullone br Discussion Here we focused on seven plant alk
2024-09-09
Discussion Here, we focused on seven plant alkaloids extracted from yokukansan. These alkaloids individually inhibited 5-HT-mediated 5-HT3A and 5-HT3AB receptor currents weakly. Simultaneous administration of these alkaloids, however, inhibited the 5-HT3A and 5-HT3AB receptor currents strongly. T
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Extracellular adenosine acts as a local
2024-09-09
Extracellular adenosine acts as a local modulator of cell function via four adenosine receptor subtypes (A1Rs A2AR, A2BR, and A3R) that are involved in numerous physiological and pathophysiological processes [31]. Each is encoded by a separate gene and has different functions, although with some ov
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Derivatives of M that possess either
2024-09-09
Derivatives of (+)-M100907 that possess either an alkyne or an azide have been synthesized. The most active enantiomer was obtained by resolution of a relatively early intermediate in the synthesis. The ability of these poly a polymerase to maintain 5-HTR antagonist properties as (+)-M100907 was dem
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br Acknowledgements Authors wish to thank Sabanci University
2024-09-09
Acknowledgements Authors wish to thank Sabanci University (Turkey), Tubitak (Cost Eu-Ros, 113Z463), and the University of Turin (Italy) for supporting this work. Beyza Vurusaner is supported by Sabanci University Post-doctoral research scholarship. Introduction Endometriosis is defined as the
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br Oxidative microbe killing and V ATPase Oxidative killing
2024-09-09
Oxidative microbe killing and V-ATPase Oxidative killing of phagocytosed microorganisms is predominately achieved through the uptake of large quantities of molecular oxygen by the infected cell and the activity particularly of the NADPH oxidase complex on phagosomes (Savina et al., 2006) and the
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Significant reductions in GYN cancer patient mortality and m
2024-09-09
Significant reductions in GYN cancer patient mortality and morbidity rates require treatments that proactively prevent and reverse resistance to chemotherapy and radiation. Combining chemotherapy and radiation with inhibitors of key DDR proteins targets is likely to enhance the ability of genotoxic
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In the nineties we knew
2024-09-09
In the nineties we knew that (-)baclofen was the stereo-selective ligand for the GABAB receptor which had been recognised by Norman Bowery as a receptor for GABA, which was different from the GABAA receptor (Hill and Bowery, 1981). GABAB receptor antagonists were also synthesised and made available
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